您可以将坐标乘以原始图像和样式图像的比率。 
<img id="paredea" usemap="#PAREDE-A"  src="https://i.imgur.com/o9nrUMR.png">
    <map name="PAREDE-A">
        <area id="paredea0" shape="rect"  onclick="alert('colmeia A')">
        <area id="paredea1" shape="rect"  onclick="alert('colmeia B')">
        <area id="paredea2" shape="rect"  onclick="alert('colmeia C')">
        <area id="paredea3" shape="rect"  onclick="alert('colmeia D')">
        <area id="paredea4" shape="rect"  onclick="alert('colmeia E')"> 
        <area id="paredea5" shape="rect"  onclick="alert('comeia F')">
        <area id="paredea6" shape="rect"  onclick="alert('colmeia G')">
        <area id="paredea7" shape="rect"  onclick="alert('colmeia H')">
        <area id="paredea8" shape="rect"  onclick="alert('colmeia I')">
        <area id="paredea9" shape="rect"  onclick="alert('colmeia J')">  
        <area id="paredea10" shape="rect"  onclick="alert('colmeia K')">
        <area id="paredea11" shape="rect"  onclick="alert('colmeia L')">
        <area id="paredea12" shape="rect"  onclick="alert('colmeia M')">
        <area id="paredea13" shape="rect"  onclick="alert('colmeia N')">
        <area id="paredea14" shape="rect"  onclick="alert('colmeia O')">  
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        coordsA[0] = "0,0,200,130";
        coordsA[1] = "200,0,400,130";
        coordsA[2] = "400,0,600,130";
        coordsA[3] = "600,0,800,130";
        coordsA[4] = "800,0,1000,130";
        coordsA[5] = "0,160,200,240";
        coordsA[6] = "200,160,400,240";
        coordsA[7] = "400,160,600,240";
        coordsA[8] = "600,160,800,240";
        coordsA[9] = "800,160,1000,240";
        coordsA[10] = "0,270,200,400";
        coordsA[11] = "200,270,400,400";
        coordsA[12] = "400,270,600,400";
        coordsA[13] = "600,270,800,400";
        coordsA[14] = "800,270,1000,400";
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            document.getElementById('paredea').style.width = "auto";
            var width1 = document.getElementById('paredea').width;
            document.getElementById('paredea').style.width = "100%";
            var width2 = document.getElementById('paredea').width;
            var ratio = width2 / width1;
            for (var i = 0; i < totalOfAreas; i++) {
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                for (var j = 0; j < temp.length; j++) {
                    temp[j] *= ratio;
                    newcoords += temp[j] + ",";
                }
                newcoords = newcoords.substr(0, newcoords.length - 1);
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            setcoords("paredea", 15);
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        window.onresize = function () {
            setcoords("paredea", 15);
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